Iron is a trace element essential for the proper functioning of the body, playing a key role in energy production, oxygen transport by hemoglobin and DNA synthesis. However, a metabolic imbalance leading to iron overload can cause excessive accumulation of this metal in various tissues, inducing cellular toxicity that can lead to serious damage to vital organs. Currently, three iron chelators are approved to treat this overload: deferoxamine, deferiprone and deferasirox. Although these treatments are effective, their potential side effects, including renal, hepatic and gastrointestinal complications, significantly limit their long-term use. Consequently, exploring alternative and better-tolerated treatments has become a priority. The use of natural, plant-derived chelators is attracting growing interest as a promising therapeutic option. In this review, eleven plants with iron-chelating properties were identified, belonging to various botanical families such as Solanaceae, Zingiberaceae, Theaceae, Ginkgoaceae, Lamiaceae, Poaceae, Moringaceae, Myrtaceae, Anacardiaceae, and Salicaceae. Among these plants, Solanaceae (Withania somnifera L., Capsicum annuum L.) and Lamiaceae (Scutellaria baicalensis G.) stand out for their richness in bioactive compounds capable of effectively binding and eliminating excess iron. This innovative approach could offer a complementary or alternative therapy to conventional treatments, thus opening new perspectives for the control and management of iron overload.